Indolopyridoquinazoline Alkaloids with Antiplatelet Aggregation Activity from Zanthoxylum integrifoliolum

Wine-Show Sheen; Ian-Lih Tsai; Che-Ming Teng; Feng-Nien Ko; Ih-Sheng Chen

doi:10.1055/s-2006-957846

Planta Medica, Table of Contents

Planta Med 1996; 62(2): 175-176
DOI: 10.1055/s-2006-957846

Letters

Indolopyridoquinazoline Alkaloids with Antiplatelet Aggregation Activity from Zanthoxylum integrifoliolum

Wine-Show Sheen¹ , Ian-Lih Tsai¹ , Che-Ming Teng² , Feng-Nien Ko² , Ih-Sheng Chen¹

¹School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Republic of China
²Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Republic of China

Abstract

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Abstract

Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC₅₀ value of ca. 1-2 µg/ml.

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